Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.

Kaichiro Haruta, Yoshiyuki Tanaka, Takuya Kawamura, Yoshinori Kondo, Akira Ono, Hiroyuki Yamakoshi, Naoki Kanoh, Yoshiharu Iwabuchi

研究成果: Article

抜粋

Unnatural "L-DNA" containing 2'-deoxy-L-ribose backbone instead of natural 2'-deoxy-D-ribose was synthesized and evaluated by (1)H NMR, CD spectra. Proton ((1)H) NMR spectra of natural DNA (D-TpT) and L-DNA (L-TpT) are fully consistent with each other. In CD spectra, however, spectrum of L-TpT was reversed, relative to that of D-TpT. These results indicate that L-TpT is an isomer with a mirror image configuration of D-TpT. In summary, we have synthesized enantiomeric L-DNA, and the L-DNA would be materials for nanodevices and tools for exploring why the D-isomer of DNA molecules was selected as a bio-molecule.

元の言語English
ページ(範囲)187-188
ページ数2
ジャーナルNucleic acids symposium series (2004)
発行部数51
DOI
出版物ステータスPublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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