Synthesis of amorfrutins B and D from amorfrutin A ethyl ester

Tadafumi Fujita, Shigefumi Kuwahara, Yusuke Ogura

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Synthesis of the geranylated dihydrostilbenoid amorfrutin B with antimicrobial, PPARγ modulating and quorum sensing inhibitory activities has been achieved from amorfrutin A ethyl ester by a seven-step sequence involving the Johnson–Claisen rearrangement to install the (E)-configured double bond on the side chain. The proposed stereoisomer of amorfrutin D and its enantiomer have been synthesized enantioselectively from the same starting material, both in nine steps, using the CBS asymmetric reduction as the key step.

本文言語English
論文番号151477
ジャーナルTetrahedron Letters
61
6
DOI
出版ステータスPublished - 2020 2 6

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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