Synthesis of a novel bioactive photoaffinity probe based on a leaf-movement factor with potential high binding affinity to its receptor molecule

Tomohiko Fujii, Takanori Sugimoto, Shosuke Yamamura, Minoru Ueda

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Nyctinastic leaf-movement is induced by the binding of the leaf-movement factor with a motor cell located in the pulvini of the plant. Some receptors of the leaf-movement factor should be involved in this biological event. We developed a novel photoaffinity probe (1) for the detection of receptor molecules. Probe compound 1 bears a photolabeling group on the 2′-position of the glycon moiety, which is near the potential binding site of the molecule with its receptor. This molecular design would be effective for the improvement of photolabeling yield.

本文言語English
ページ(範囲)2497-2499
ページ数3
ジャーナルTetrahedron Letters
44
12
DOI
出版ステータスPublished - 2003 3 17
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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