Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara, Fumi Nagatsugi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity.

本文言語English
ページ(範囲)6957-6961
ページ数5
ジャーナルBioorganic and Medicinal Chemistry Letters
22
22
DOI
出版ステータスPublished - 2012 11 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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