Synthesis of 5-Azaindolizine Derivatives by the Palladium-Catalyzed Intermolecular Formal [3+2] Cycloaddition of Alkylidenecyclopropanes with 1,2-Diazines

Amal I. Siriwardana, Itaru Nakamura, Yoshinori Yamamoto

研究成果: Article査読

51 被引用数 (Scopus)

抄録

The palladium-catalyzed formal [3+2] cycloaddition reaction of alkylidenecyclopropanes with 1,2-diazines proceeded smoothly to give the corresponding 5-azaindolizine derivatives in good to allowable yields. For example, in the presence of 5 mol % of Pd(PPh3)4, the reaction of 1-propyl-hexylidenecyclopropane with phthalazine or with pyridazine proceeded at 120 °C without solvent, and the corresponding 2-(1-butylpentyl)pyrrolo[2,1-a]phthalazine or 6-(1-butylpentyl)pyrrolo[1,2-b]pyridazine was obtained in 61% or 49% yield, respectively.

本文言語English
ページ(範囲)3202-3204
ページ数3
ジャーナルJournal of Organic Chemistry
69
9
DOI
出版ステータスPublished - 2004 4 30

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

「Synthesis of 5-Azaindolizine Derivatives by the Palladium-Catalyzed Intermolecular Formal [3+2] Cycloaddition of Alkylidenecyclopropanes with 1,2-Diazines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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