Synthesis of 2,3-disubstituted indoles by radical cyclization with hypophosphorous acid and its application to total synthesis of (±)-catharanthine

Matthew T. Reding, Yosuke Kaburagi, Hidetoshi Tokuyama, Tohru Fukuyama

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Radical cyclization of o-alkenylthioanilides using hypophosphorous acid and AIBN in the presence of Et3N proceeded smoothly to furnish the corresponding 2,3-disubstituted indoles in high yields. Utilizing the newly developed cyciization condition, a stereocontrolled total synthesis of (±)-catharanthine has been completed.

本文言語English
ページ(範囲)313-330
ページ数18
ジャーナルHeterocycles
56
1-2
DOI
出版ステータスPublished - 2002 1 1
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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