Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins

Shibaji K. Ghosh, Mark S. Butler, Martin J. Lear

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway.

本文言語English
ページ(範囲)2706-2708
ページ数3
ジャーナルTetrahedron Letters
53
22
DOI
出版ステータスPublished - 2012 5 30

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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