Synthesis of 1-11C-labeled fatty acid from [11C]HCN

Toshihiro Takahashi, Tatsuo Ido, Kentaro Hatano, Ren Iwata, Hiroaki Nakanishi

研究成果: Article査読

9 被引用数 (Scopus)

抄録

A new chemical approach to the preparation of [1-11C]fatty acids from [11C]HCN has been developed. Four straight chain [1-11C]fatty acids (C15C18) and one branched chain [1-11C]fatty acid (3-methylheptadecanoic acid) were produced by the reaction of alkyl bromides with 11CN- and subsequent hydrolysis. The synthesis time was 47-67 min after the end of bombardment, with radiochemical yields of 16-20 mCi (70-83%) for a series of straight chain [1-11C]fatty acids and 4-8 mCi (33-42%) for 3-methyl [1-11C]heptadecanoic acid (from 120 mCi of trapped [11C]HCN). This method has some advantages, such as no requirement of absolutely anhydrous solvent, easy 11C-labeling using an extremely small amount of substrate, and good reproducibility.

本文言語English
ページ(範囲)649-654
ページ数6
ジャーナルInternational Journal of Radiation Applications and Instrumentation. Part
41
7
DOI
出版ステータスPublished - 1990
外部発表はい

ASJC Scopus subject areas

  • 放射線
  • 工学(全般)

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