Synthesis and substitution reactions of 4(6)-chlorodihydropyrimidines

Hidetsura Cho, Yoshizumi Yasui, Satoshi Kobayashi, Eunsang Kwon, Mieko Arisawa, Masahiko Yamaguchi

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Chlorination of the corresponding ketones with phenylphosphonic dichloride (PhPOCl2) provided ethyl 6(4)-chloro-2-methyl-4(6)-phenyl-1,4(6)- dihydropyrimidine-5-carboxylate in good yield. The cross-coupling reactions of organoboronic acids or triethylborane with 1-tert-butyl 5-ethyl 4-chloro-2- methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate synthesized by regiospecific alkoxycarbonylation of the chlorinated dihydropyrimidine afforded 1,4(3,4)-dihydropyrimidines having a variety of functional groups at position-6(4) in good to excellent yields.

本文言語English
ページ(範囲)1807-1818
ページ数12
ジャーナルHeterocycles
83
8
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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