Synthesis and stereochemistry of glaucoposterol A and strophasterol D

Shuntaro Sato, Yuka Taguchi, Shigefumi Kuwahara

研究成果: Article査読

抄録

The proposed structure of glaucoposterol A, a strophastane-type steroid of mushroom origin, has been synthesized from an aldol obtained in our previous synthesis of strophasterol F, a diastereomer of the proposed structure of glaucoposterol A. Based on the fact that the NMR data of natural glaucoposterol A are distinctly different from those of the synthetic material, but matches those of strophasterol F, we put forward a proposal that glaucoposterol A and strophasterol F are actually the same compound. In addition, the hitherto unknown stereochemistry of strophasterol D has been elucidated through synthesis of its two diastereomeric structures.

本文言語English
論文番号131129
ジャーナルTetrahedron
76
17
DOI
出版ステータスPublished - 2020 4 24

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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