Synthesis and photophysical properties of covalent conjugates of aqua platinum(II) and octacarboxy-substituted zinc phthalocyanine

Roman A. Bulgakov, Nina A. Kuznetsova, Olga V. Dolotova, Ludmila I. Solovieva, John Mack, Wadzanai J.U. Chidawanyika, Oleg L. Kaliya, Tebello Nyokong

研究成果: Article査読

6 被引用数 (Scopus)

抄録

New covalent conjugates of aqua platinum(II) and octacarboxy-substituted zinc phthalocyanine, bearing one, two, three and four aqua platinum moieties on the periphery of the Pc ligand have been synthesized and characterized. The effect of the stepwise introduction of the aqua platinums on the photophysical and photochemical properties of these compounds has been investigated in dimethylsulfoxide solution. It has been found that aqua platinum moieties have only a limited effect on the dynamics of the singlet and triplet excited states, on the ability to sensitize singlet oxygen formation and on the photostability. Each conjugate has a high singlet oxygen quantum yield (Φ 0.510.62) and thus retains potential for use as a dual action anticancer drugs by acting as a sensitizer for PDT in addition to the likely chemotherapeutic effects of the Pt(II) complexes.

本文言語English
ページ(範囲)1217-1224
ページ数8
ジャーナルJournal of Porphyrins and Phthalocyanines
16
11
DOI
出版ステータスPublished - 2012 11月

ASJC Scopus subject areas

  • 化学 (全般)

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