Synthesis and optical resolution of an anti-O,O′-dialkylated calix[4]arene

Fumitaka Narumi; Waka Yamabuki; Tetsutaro Hattori; Hiroshi Kameyama; Sotaro Miyano

doi:10.1246/cl.2003.320

Synthesis and optical resolution of an anti-O,O′-dialkylated calix[4]arene

Fumitaka Narumi, Waka Yamabuki, Tetsutaro Hattori, Hiroshi Kameyama, Sotaro Miyano

工学研究科・バイオ工学専攻

研究成果: Article › 査読

17 被引用数 (Scopus)

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Proximally O,O′-disiloxane-bridged calix[4]arene (1) was treated with benzyl bromide in the presence of Cs₂CO₃ to afford, after desilylation, anti-O,O′-dibenzylcalix[4]arene (4a) in 90% yield. Chromatographic separation of its diastereomeric (S)-2-methoxy-2-(1-naphthyl)propionic esters allowed the first optical resolution of this kind of dialkylated calix[4]arenes.

本文言語	English
ページ（範囲）	320-321
ページ数	2
ジャーナル	Chemistry Letters
巻	32
号	4
DOI	https://doi.org/10.1246/cl.2003.320
出版ステータス	Published - 2003 4月 5

ASJC Scopus subject areas

化学 (全般)

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10.1246/cl.2003.320

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AU - Kameyama, Hiroshi

AU - Miyano, Sotaro

PY - 2003/4/5

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AB - Proximally O,O′-disiloxane-bridged calix[4]arene (1) was treated with benzyl bromide in the presence of Cs2CO3 to afford, after desilylation, anti-O,O′-dibenzylcalix[4]arene (4a) in 90% yield. Chromatographic separation of its diastereomeric (S)-2-methoxy-2-(1-naphthyl)propionic esters allowed the first optical resolution of this kind of dialkylated calix[4]arenes.

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Synthesis and optical resolution of an anti-O,O′-dialkylated calix[4]arene

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