Synthesis and guest-binding study of polytopic multi(cyclophane) hosts

Osamu Hayashida, Yousuke Takaoka, Itaru Hamachi

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Novel bis(cyclophanes) bearing glucosides and pentakis(cyclophanes) bearing glucosides were prepared as water-soluble hosts by connecting two or five macrocyclic skeletons, respectively. The guest-binding affinities of the present bis(cyclophanes) and pentakis(cyclophanes) toward a hydrophobic dye, 6-p-toluidinonaphthalene-2-sulfonate, were enhanced 13- and 1200-fold, respectively, relative to that by a corresponding monocyclic cyclophane, reflecting multivalency effects in macrocycles.

本文言語English
ページ(範囲)6589-6592
ページ数4
ジャーナルTetrahedron Letters
46
38
DOI
出版ステータスPublished - 2005 9月 19
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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