Synthesis and biological activities of reveromycin A and spirofungin A derivatives

Takeshi Shimizu, Takeo Usui, Makoto Fujikura, Makoto Kawatani, Tomoharu Satoh, Kiyotaka Machida, Naoki Kanoh, Je Tae Woo, Hiroyuki Osada, Mikiko Sodeoka

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of srcts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.

本文言語English
ページ(範囲)3756-3760
ページ数5
ジャーナルBioorganic and Medicinal Chemistry Letters
18
13
DOI
出版ステータスPublished - 2008 7 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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