Synthesis and biological activities of reveromycin A and spirofungin A derivatives

Takeshi Shimizu; Takeo Usui; Makoto Fujikura; Makoto Kawatani; Tomoharu Satoh; Kiyotaka Machida; Naoki Kanoh; Je Tae Woo; Hiroyuki Osada; Mikiko Sodeoka

doi:10.1016/j.bmcl.2008.05.054

Synthesis and biological activities of reveromycin A and spirofungin A derivatives

Takeshi Shimizu, Takeo Usui, Makoto Fujikura, Makoto Kawatani, Tomoharu Satoh, Kiyotaka Machida, Naoki Kanoh, Je Tae Woo, Hiroyuki Osada, Mikiko Sodeoka

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

16 被引用数 (Scopus)

抄録

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of src^ts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.

本文言語	English
ページ（範囲）	3756-3760
ページ数	5
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	18
号	13
DOI	https://doi.org/10.1016/j.bmcl.2008.05.054
出版ステータス	Published - 2008 7 1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

文献へのアクセス

10.1016/j.bmcl.2008.05.054

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引用スタイル

Synthesis and biological activities of reveromycin A and spirofungin A derivatives. / Shimizu, Takeshi; Usui, Takeo; Fujikura, Makoto; Kawatani, Makoto; Satoh, Tomoharu; Machida, Kiyotaka; Kanoh, Naoki; Woo, Je Tae; Osada, Hiroyuki; Sodeoka, Mikiko.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 13, 01.07.2008, p. 3756-3760.

研究成果: Article › 査読

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abstract = "Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of srcts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.",

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AU - Shimizu, Takeshi

AU - Usui, Takeo

AU - Fujikura, Makoto

AU - Kawatani, Makoto

AU - Satoh, Tomoharu

AU - Machida, Kiyotaka

AU - Kanoh, Naoki

AU - Woo, Je Tae

AU - Osada, Hiroyuki

AU - Sodeoka, Mikiko

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KW - Osteoclasts

KW - Reveromycin A

KW - Spirofungin A

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