Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid

Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Kiyotaka Nakagawa, Teruo Miyazawa

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Rice bran consists of many functional compounds and thus much attention has been focused on the health benefits of its components. Here, we investigated the synergistic inhibitory effects of its components, particularly δ-tocotrienol (δ-T3) and ferulic acid (FA), against the proliferation of an array of cancer cells, including DU-145 (prostate cancer), MCF-7 (breast cancer), and PANC-1 (pancreatic cancer) cells. The combination of δ-T3 and FA markedly reduced cell proliferation relative to δ-T3 alone, and FA had no effect when used alone. Although δ-T3 induced G1 arrest by up-regulating p21 in PANC-1 cells, more cells accumulated in G1 phase with the combination of δ-T3 and FA. This synergistic effect was attributed to an increase in the cellular concentration of δ-T3 by FA. Our results suggest that the combination of δ-T3 and FA may present a new strategy for cancer prevention and therapy.

本文言語English
ページ(範囲)606-611
ページ数6
ジャーナルBiochemical and biophysical research communications
453
3
DOI
出版ステータスPublished - 2014 10 24

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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