Surgical Approaches to Advanced Gallbladder Cancer: A 40-Year Single-Institution Study of Prognostic Factors and Resectability

Ryota Higuchi, Takehiro Ota, Tatsuo Araida, Hideki Kajiyama, Takehisa Yazawa, Toru Furukawa, Tatsuya Yoshikawa, Ken Takasaki, Masakazu Yamamoto

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Purpose: The aim was to evaluate prognostic factors and factors associated with the resectability of advanced gallbladder cancer (GBC).

Methods: This was a single-institution retrospective review of 274 consecutive surgically-treated cases of advanced GBC (excluding incidental GBC and early GBC). Univariate and multivariate analysis were performed to assess prognostic variables. R0 resection and survival rates were investigated for each local extension factor.

Results: Long-term survival was uncommon among patients with multiple liver metastases (H2–3: n = 22; 2-year survival, 0 %), dissemination (P1–3: n = 16; 3-year survival, 0 %), invasion through the hepatoduodenal ligament (Binf3: n = 45; 5-year survival, 4.6 %), or group 3 lymph node (LN) metastasis including of the para-aortic LN (N3: n = 52; 13.7 %). Long-term survival rates did not differ significantly between patients who did and did not undergo bile duct resection or pancreaticoduodenectomy. Survival did not differ significantly according to the type of hepatectomy performed.

Conclusion: Surgery may not be indicated for patients with multiple liver metastasis, dissemination, Binf3, or visible para-aortic LN metastasis. Furthermore, it is important to achieve R0 surgery in cases of GBC.

本文言語English
ページ(範囲)4308-4316
ページ数9
ジャーナルAnnals of Surgical Oncology
21
13
DOI
出版ステータスPublished - 2014 10 31
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 腫瘍学

フィンガープリント

「Surgical Approaches to Advanced Gallbladder Cancer: A 40-Year Single-Institution Study of Prognostic Factors and Resectability」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル