Surface modification by grafting with biocompatible 2-methacryloyloxyethyl phosphorylcholine for microfluidic devices

James Sibarani, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Non-biofouling surfaces with polymer-based substrate were prepared for manufacturing microfluidic devices. It was done by constructing biocompatible poly(2-methacryloyloxyethyl phosphorylcholine(MPC)) brushes using surface-initiated graft polymerization method based on dithiocarbamate as photoiniferter. The density and length of the polymer chains were varied by changing the composition of the photoiniferter moiety in the base polymer (macrophotoiniferter) and the photoirradiation time, respectively. The molecular weight and thickness of the poly(MPC)-grafted chains were 320 kDa and 95 ±14 nm, respectively. Characterizations of the poly(MPC) modified surfaces were conducted by water contact angle, X-ray photoelectron spectroscopy, atomic force microscope. Protein adsorption resistance of these modified surfaces was then investigated by contacting with human plasma protein dissolved in phosphate buffered saline. These poly(MPC)-modified surfaces effectively reduced protein adsorption.

本文言語English
ページ(範囲)789-792
ページ数4
ジャーナルKey Engineering Materials
342-343
DOI
出版ステータスPublished - 2007 1 1
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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