Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period

Y. Hosoi, K. Sakamoto

研究成果: Article査読

78 被引用数 (Scopus)

抄録

The dose dependency and effective period of suppressive effects by low dose total body irradiation (TBI) in both artificial and spontaneous lung metastasis were investigated using marine squamous cell carcinoma. In the artificial lung metastasis of the tumour cells injected through a tail vein, the TBI of 0.15-0.20 Gy resulted in significant net suppression of lung colony formation. With this dose range, the effective period lasted for 12 h ranging from 9 h before to 3 h after the tumour cell injection. Similar suppressive effect was also observed in the spontaneous lung metastasis. These data suggest that careful assessment of effective dose and duration of low dose TBI on human metastasis could provide a new therapy to suppress clinical metastasis.

本文言語English
ページ(範囲)177-179
ページ数3
ジャーナルRadiotherapy and Oncology
26
2
DOI
出版ステータスPublished - 1993 2月

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 放射線学、核医学およびイメージング

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