@article{51ffaf89d5244491b6d64c51803698d4,
title = "Supplementation with fermented rice bran attenuates muscle atrophy in a diabetic rat model",
abstract = "Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 (p < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions.",
keywords = "Anti-inflammation, Diabetes mellitus, FBXO32/Atrogin-1, Fermented rice bran, Muscle atrophy, NF-κB, Streptozotocin, TRIM63/MuRF1",
author = "Rusbana, {Tubagus Bahtiar} and Agista, {Afifah Zahra} and Saputra, {Wahyu Dwi} and Yusuke Ohsaki and Kouichi Watanabe and Ardy Ardiansyah and Slamet Budijanto and Takuya Koseki and Hisashi Aso and Michio Komai and Hitoshi Shirakawa",
note = "Funding Information: Acknowledgments: We are grateful to the Islamic Development Bank via the development of four higher education institution projects (4 in 1 project), the Indonesia Center of Excellence for Food Security of Sultan Ageng Tirtaysa University, and to the Indonesian Ministry of Research, Technology, and Higher Education for the fundamental research grant of S.B. for administrative support to T.B.R. Funding Information: Funding: This work was partially supported by grants from the Bilateral Joint Research Projects of the Japan Society for the Promotion of Science (JSPS), the JSPS Core-to-Core Program A (Advanced Research Networks) “Establishment of international agricultural immunology research-core for a quantum improvement in food safety”, the Tojuro Iijima Foundation for Food Science and Technology, and the Joint Projects of Rice Bran of Sunstar Inc. Publisher Copyright: {\textcopyright} 2020 by the authors.",
year = "2020",
month = aug,
doi = "10.3390/nu12082409",
language = "English",
volume = "12",
pages = "1--14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",
}
