Supplementation with fermented rice bran attenuates muscle atrophy in a diabetic rat model

Tubagus Bahtiar Rusbana, Afifah Zahra Agista, Wahyu Dwi Saputra, Yusuke Ohsaki, Kouichi Watanabe, Ardy Ardiansyah, Slamet Budijanto, Takuya Koseki, Hisashi Aso, Michio Komai, Hitoshi Shirakawa

研究成果: Article

抜粋

Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 (p < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions.

元の言語English
記事番号2409
ページ(範囲)1-14
ページ数14
ジャーナルNutrients
12
発行部数8
DOI
出版物ステータスPublished - 2020 8

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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    Rusbana, T. B., Agista, A. Z., Saputra, W. D., Ohsaki, Y., Watanabe, K., Ardiansyah, A., Budijanto, S., Koseki, T., Aso, H., Komai, M., & Shirakawa, H. (2020). Supplementation with fermented rice bran attenuates muscle atrophy in a diabetic rat model. Nutrients, 12(8), 1-14. [2409]. https://doi.org/10.3390/nu12082409