[18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism

Masanobu Chida, Yutaka Kagaya, Shinji Nagata, Masanori Mukoyoshi, Shigeto Namiuchi, Yuriko Yamane, Nobumasa Ishide, Jun Watanabe, Toshihiro Takahashi, Tatsuo Ido, Kunio Shirato

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.

本文言語English
ページ(範囲)815-819
ページ数5
ジャーナルNuclear Medicine and Biology
28
7
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 放射線学、核医学およびイメージング
  • 癌研究

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