Sulfotransferase catalyzing sulfation of heterocyclic amines

Y. Yamazoe, K. Nagata, K. Yoshinari, K. Fujita, T. Shiraga, K. Iwasaki

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Cytosolic sulfation of arylamines to form sulfamates is found to be mediated by sulfotransferases of three gene families (SULT1 to 3). Among them, a SULT3 form (ST3A1) showed a high selectivity for N-sulfation of N-substituted aryl and alicyclic compounds. SULT1 (phenol) and SULT2 (hydroxysteroid) sulfotransferases showed N-sulfating activities of carcinogenic heterocyclic amines. For N-hydroxyarylamine O-sulfation, SULT1 forms showed high activity. In rats, ST1C1 mediated the metabolic activation of N-hydroxyarylamines. However, the related form (ST1C2) in humans showed the negligible activity. Instead, ST1A3 showed high metabolic activating abilities among human sulfotransferases. Copyright (C) 1999 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)103-107
ページ数5
ジャーナルCancer Letters
143
2
DOI
出版ステータスPublished - 1999 9 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント 「Sulfotransferase catalyzing sulfation of heterocyclic amines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル