Sugar based γ-amino alcohol organocatalyst for asymmetric Michael addition of β-keto esters with nitroolefins

Divakar Ganesan, Madhu Chennapuram, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Sugar based γ-amino alcohol was used in asymmetric Michael addition of β-keto esters with nitroolefins for the first time affording the corresponding several chiral Michael adducts bearing quaternary chiral carbon center in moderate to good chemical yields and stereoselectivities (up to 98%, up to dr. 95:5, up to 84% ee).

本文言語English
ページ(範囲)1536-1545
ページ数10
ジャーナルHeterocycles
98
11
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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