Sudden infant death from dilated cardiomyopathy with endocardial fibroelastosis

Shirushi Takahashi, Jun Kanetake, Takuya Moriya, Masato Funayama

研究成果: Article査読

6 被引用数 (Scopus)


A four-month-old female with no previous medical history suddenly collapsed and failed to recover despite 2 h of resuscitation. An autopsy showed marked cardiomegaly (88 g) with prominent dilatation of the left ventricle and a whitish opacity on the endocardial surface. The ductus arteriosus was patent, but both orifices were severely stenosed. Microscopically, the endocardium showed pronounced thickening with laminar deposition of elastic and collagen fibers. Additionally, there was a mixture of myocardial fibers with a marked "wavy" appearance and a scattering of mild interstitial lymphocytic infiltration. We believe that endocardial thickening in this infant met the diagnostic criteria for endocardial fibroelastosis (EFE). Although it is controversial whether primary EFE is a distinct pathologic entity or an epiphenomenon, we speculated that "dilated cardiomyopathy with EFE" had caused the decedent's death based on the appearance of the myocardial fibers.

ジャーナルLegal Medicine
出版ステータスPublished - 2008 9

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

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