Subtyping of primary aldosteronism in the AVIS-2 study: Assessment of selectivity and lateralization

Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultzekool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter FullerJun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Chin Chen Chang, Vin Cent Wu, Zusana Somloova, Giuseppe Maiolino, Giulio Barbiero, Michele Battistel, Livia Lenzini, Emilio Quaia, Achille Cesare Pessina, Gian Paolo Rossi

研究成果: Article査読

22 被引用数 (Scopus)


Context: Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism(PA), but its interpretation varies widely across referral centers and this can adversely affect themanagement of PA patients.Objectives: To investigate in a real-life study the rate of bilateral success and identification ofunilateral aldosteronism and their impact on blood pressure outcomes in PA subtyped by AVS.Design and settings: In a retrospective analysis of the largest international registry of individual AVS data (AVIS-2 study), we investigated how different cut-off values of the selectivity index(SI) and lateralization index (LI) affected rate of bilateral success, identification of unilateralaldosteronism, and blood pressure outcomes.Results: AVIS-2 recruited 1625 individual AVS studies performed between 2000 and 2015 in 19tertiary referral centers. Under unstimulated conditions, the rate of biochemically confirmedbilateral AVS success progressively decreased with increasing SI cut-offs; furthermore, withcurrently used LI cut-offs, the rate of identified unilateral PA leading to adrenalectomy wasas low as <25%. A within-patient pairwise comparison of 402 AVS performed both underunstimulated and cosyntropin-stimulated conditions showed that cosyntropin increased theconfirmed rate of bilateral selectivity for SI cut-offs = 2.0, but reduced lateralization rates(P < 0.001). Post-adrenalectomy outcomes were not improved by use of cosyntropin or morerestrictive diagnostic criteria.Conclusion: Commonly used SI and LI cut-offs are associated with disappointingly low ratesof biochemically defined AVS success and identified unilateral PA. Evidence-based protocolsentailing less restrictive interpretative cut-offs might optimize the clinical use of this costly andinvasive test.

ジャーナルJournal of Clinical Endocrinology and Metabolism
出版ステータスPublished - 2020 6 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学


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