Substrate specificity of urate transporter in rat renal brush border membranes

Takashi Dan, Hiroshi Koga

研究成果: Article査読

4 被引用数 (Scopus)

抄録

To further demonstrate the substrate specificity of urate-anion exchanger in rat renal brush border membrane vesicles, the hydroxyl ion gradient-dependent [2-14C] urate uptake was studied by a rapid filtration technique. The [2-14C] urate uptake was more sensitive to unlabeled urate than to unlabeled xanthine and hypoxanthine. In addition, urate derivatives which are methylated at the positions 3 and 9 hardly inhibited the urate uptake. Because of the substrate specificity, the urate-anion exchanger in brush border membranes appears to selectively use urate as the endogenous substrate.

本文言語English
ページ(範囲)1963-1968
ページ数6
ジャーナルLife Sciences
48
20
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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