Subcortical brain volume abnormalities in individuals with an at-risk mental state

Daiki Sasabayashi, Yoichiro Takayanagi, Tsutomu Takahashi, Naoyuki Katagiri, Atsushi Sakuma, Chika Obara, Masahiro Katsura, Naohiro Okada, Shinsuke Koike, Hidenori Yamasue, Mihoko Nakamura, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, Kiyoto Kasai, Michio Suzuki

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Previous structural magnetic resonance imaging studies of psychotic disorders have demonstrated volumetric alterations in subcortical (ie, the basal ganglia, thalamus) and temporolimbic structures, which are involved in high-order cognition and emotional regulation. However, it remains unclear whether individuals at high risk for psychotic disorders with minimal confounding effects of medication exhibit volumetric changes in these regions. This multicenter magnetic resonance imaging study assessed regional volumes of the thalamus, caudate, putamen, nucleus accumbens, globus pallidus, hippocampus, and amygdala, as well as lateral ventricular volume using FreeSurfer software in 107 individuals with an at-risk mental state (ARMS) (of whom 21 [19.6%] later developed psychosis during clinical follow-up [mean = 4.9 years, SD = 2.6 years]) and 104 age- and gender-matched healthy controls recruited at 4 different sites. ARMS individuals as a whole demonstrated significantly larger volumes for the left caudate and bilateral lateral ventricles as well as a smaller volume for the right accumbens compared with controls. In male subjects only, the left globus pallidus was significantly larger in ARMS individuals. The ARMS group was also characterized by left-greater-than-right asymmetries of the lateral ventricle and caudate nucleus. There was no significant difference in the regional volumes between ARMS groups with and without later psychosis onset. The present study suggested that significant volume expansion of the lateral ventricle, caudate, and globus pallidus, as well as volume reduction of the accumbens, in ARMS subjects, which could not be explained only by medication effects, might be related to general vulnerability to psychopathology.

本文言語English
ページ(範囲)834-845
ページ数12
ジャーナルSchizophrenia Bulletin
46
4
DOI
出版ステータスPublished - 2020 7 1

ASJC Scopus subject areas

  • 精神医学および精神衛生

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