Molecular recognition of histamine by Zn(II)-protoporphyrin (ZnPP) in water was investigated by using UV-Vis titration. An NOE mode of 1 H NMR was used to study the host-guest binding in DMSO-d 6 solution. Changes of proton chemical shifts for both ZnPP and histamine before and after complexing and a computer aided structure simulation confirmed our suggested binding mode that two hydrogen bonds between amino group of histamine and the two carboxylic acid groups of ZnPP as well as coordination of zinc to imidazole contribute to the binding.
|ジャーナル||Acta Chimica Sinica|
|出版ステータス||Published - 2004 12 1|
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