Study of the binding mode of a chromophoric host zinc protoporphyrin with histamine

Ai Jun Tong, Chun Yuan Tong, Qing Yi Yang, Yuichi Kato, Seiichi Nishizawa, Norio Teramae

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Molecular recognition of histamine by Zn(II)-protoporphyrin (ZnPP) in water was investigated by using UV-Vis titration. An NOE mode of 1 H NMR was used to study the host-guest binding in DMSO-d 6 solution. Changes of proton chemical shifts for both ZnPP and histamine before and after complexing and a computer aided structure simulation confirmed our suggested binding mode that two hydrogen bonds between amino group of histamine and the two carboxylic acid groups of ZnPP as well as coordination of zinc to imidazole contribute to the binding.

本文言語English
ページ(範囲)905-910
ページ数6
ジャーナルActa Chimica Sinica
62
9
出版ステータスPublished - 2004 12 1

ASJC Scopus subject areas

  • Chemistry(all)

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