Study of leaving groups for the preparation of [ω-18F]fluorofatty acids via nucleophilic fluorination and its application to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid

Toshihiro Takahashi, Tatsuo Ido, Ren Iwata

    研究成果: Article査読

    11 被引用数 (Scopus)

    抄録

    The effect of leaving groups on the introduction of [18F]fluorine into fatty acids via nucleophilic fluorination has been systematically studied. It has been proved that tosylate and bromide are the most reactive among such leaving groups as chloride, bromide, iodide, mesylate, tosylate and triflate. This result has been applied to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid used in routine medical studies. Using methyl 17-bromo-3-methylheptadecanoate, the 18F-labeled 3-methyl-branched fatty acid has been prepared in a radiochemical yield of 36-58% (based on 18F-) with radiochemical purities of > 97%.

    本文言語English
    ページ(範囲)801-809
    ページ数9
    ジャーナルInternational Journal of Radiation Applications and Instrumentation. Part
    42
    9
    DOI
    出版ステータスPublished - 1991

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)

    フィンガープリント 「Study of leaving groups for the preparation of [ω-<sup>18</sup>F]fluorofatty acids via nucleophilic fluorination and its application to the synthesis of 17-[<sup>18</sup>F]fluoro-3-methylheptadecanoic acid」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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