The effect of leaving groups on the introduction of [18F]fluorine into fatty acids via nucleophilic fluorination has been systematically studied. It has been proved that tosylate and bromide are the most reactive among such leaving groups as chloride, bromide, iodide, mesylate, tosylate and triflate. This result has been applied to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid used in routine medical studies. Using methyl 17-bromo-3-methylheptadecanoate, the 18F-labeled 3-methyl-branched fatty acid has been prepared in a radiochemical yield of 36-58% (based on 18F-) with radiochemical purities of > 97%.
|ジャーナル||International Journal of Radiation Applications and Instrumentation. Part|
|出版ステータス||Published - 1991|
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