Study for catecholamine-2′-deoxyguanosine adduct formation under biomimetic conditions using liquid chromatography-electrospray ionization-ion trap mass spectrometry

T. Oe, S. Matsumoto, T. Toyo'oka

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The adduct formation of 2′-deoxyguanosine (dG) with L-adrenaline under biomimetic conditions (pH 7.5, 37°C) with or without oxidant (MnO2) was demonstrated in order to clarify the reaction mechanism and the structure. At least two adducts have been observed by liquid chromatography-electrospray ionization-ion trap mass spectrometry (LC-ESI-ion trap MS) and LC-photodiode array detection (LC-PAD) (compound a: more polar than dG, m/z 463 (M+H)+, λmax: 230, 320 nm; compound b: less polar than dG, m/z 445 (M+H)+, λmax: 220, 240, 320, 405 nm). Compound a appeared only in the early stage of the reaction prior to formation of compound b.

本文言語English
ページ(範囲)339-345
ページ数7
ジャーナルJournal of Health Science
47
4
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 毒物学
  • 健康、毒物学および変異誘発

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