Studies on the site of renal tubular defect in Bartter’s syndrome

Masahiro Kikuchi, Mariko Sato, Akiko Chiba, Yasushi Chiba, Kazuya Nagao, Toshiyuki Suzuki, Yoko Fujigaki, Hisao Hoshino

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Renal tubular function was studied in an 8-month-old male infant with Bartter’s syndrome, which is characterized by hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and reduced pressor response to angiotensin II. Chloride transport along the diluting segment (CH2O/CH2O + CCl) was impaired. Furthermore, furosemide did not elicit normal natriuresis, which suggested impaired chloride reabsorptive capacity at the furosemide-sensitive ascending limb of Henle’s loop. Loss of antidiuretic hormone-mediated urinary concentration was in support of this. These findings pointed to the thick ascending limb of Henle’s loop as the site of the primary defect in this child.

本文言語English
ページ(範囲)358-361
ページ数4
ジャーナルPediatrics International
39
3
DOI
出版ステータスPublished - 1997 6
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康

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