Studies on the mechanism of drug distribution in tissues

T. Terasaki

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

The importance to elucidate the mechanisms of drug distribution in tissues has been discussed in this review. By considering several factors such as tissue binding, plasma binding, membrane permeability and tissue interstitial fluid space, the tissue distribution states of drug have been characterized based on the biochemical and pharmacokinetic studies. These physiological pharmacokinetic analyses have been applied to evaluate the determinant factors of inter-organ, drug to drug, interspecies or age related changes of tissue distribution of drug. The mechanisms of membrane permeability of drug which could play the most important role to regulate the drug distribution have been discussed. The drug distribution to the brain is strictly restricted by the function of the blood-brain barrier (BBB). The drug transport mechanisms at he BBB have been discussed. Especially, the role of carrier-mediated and absorptive-mediated transport systems at the BBB has been focused on.

本文言語English
ページ(範囲)887-905
ページ数19
ジャーナルYakugaku Zasshi
112
12
DOI
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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