Studies on the constituents of Gentiana species. II. A new triterpenoid, and (S)-(+)- and (R)-(-)-gentiolactones from Gentiana lutea

Rie Kakuda, Koichi Machida, Yasunori Yaoita, Masafumi Kikuchi, Masao Kikuchi

研究成果: Article

25 引用 (Scopus)

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A new triterpenoid, 12-ursene-3β, 11 α-diol 3-O-palmitate (1), has been isolated from the rhizomes and roots of Gentiana lutea, together with the artificial diene derivative, 9 (11), 12-ursadien-3β-ol 3-O-palmitate (1a) and five known compounds (3 - 7). Their structures were established on the basis of spectral analysis. In addition, (±)-gentiolactone [(±)-2], isolated from this plant, was successfully separated into its enantiomers [(+)-2, (-)-2] for the first time, and the absolute configurations at C-9 of (+)-2, (-)-2 were assigned as S and R, respectively, from the optical rotations and the circular dichroism (CD) spectral data.

元の言語English
ページ(範囲)885-887
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
51
発行部数7
DOI
出版物ステータスPublished - 2003 7

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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