The arylation of 2-, 4-, and 5-halopyrimidines with aryltributylstannanes in the presence of dichlorobis-(triphenylphosphine)palladium was investigated with successful results. The reaction can be expanded to the synthesis of 2-, 4-, and 5-vinylpyrimidines with generality. The site-selectivity of the reaction for 4,5-dihalopyrimidines is also described.
ASJC Scopus subject areas
- 化学 (全般)