Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses

Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.

本文言語English
ページ(範囲)4624-4627
ページ数4
ジャーナルOrganic letters
13
17
DOI
出版ステータスPublished - 2011 9 2

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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