Structure and stability studies of mixed monolayers of saturated and unsaturated phospholipids under low-level ozone

Lin Qiao, Aimin Ge, Masatoshi Osawa, Shen Ye

研究成果: Article査読

25 被引用数 (Scopus)

抄録

In the present study, stability and structure of single and binary mixed monolayers of an unsaturated phospholipid, DOPC, and a saturated phospholipid, DPPC-d75, on the water surface, were explored using the π-A isotherm, atomic force microscopy (AFM) and sum frequency generation (SFG) vibrational spectroscopy in various environments. Our results demonstrated that DOPC in the monolayers becomes unstable after the exposure to a low concentration of ozone (20 ± 10 ppb) or even to ambient laboratory air, which has a similar ozone level, but is stable in nitrogen or oxygen. DOPC can be selectively oxidized by a trace amount of ozone in the ambient environment but can be partially inhibited by the presence of DPPC in the monolayer. The present study provides useful information for understanding the physicochemical properties of the cell membranes.

本文言語English
ページ(範囲)17775-17785
ページ数11
ジャーナルPhysical Chemistry Chemical Physics
15
41
DOI
出版ステータスPublished - 2013 11 7
外部発表はい

ASJC Scopus subject areas

  • 物理学および天文学(全般)
  • 物理化学および理論化学

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