Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

Makoto Ishikawa, Yu Sawada, Takeshi Yoshitomi

研究成果: Article査読

49 被引用数 (Scopus)

抄録

The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.

本文言語English
ページ(範囲)3-18
ページ数16
ジャーナルExperimental Eye Research
133
DOI
出版ステータスPublished - 2015 4 1
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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