Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1

Ichiro Takahashi, Shozo Kotani, Haruhiko Takada, Teisuo Shiba, Shoichi Kusumoto

研究成果: Article査読

17 被引用数 (Scopus)

抄録

A variety of compounds, synthetic, semisynthetic or bacterial, which corre-sponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.

本文言語English
ページ(範囲)188-206
ページ数19
ジャーナルBlood Purification
6
3
DOI
出版ステータスPublished - 1988
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腎臓病学

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