Structural model of the amyloid fibril formed by β2- microglobulin #21-31 fragment based on vibrational spectroscopy

Hirotsugu Hiramatsu, Yuji Goto, Hironobu Naiki, Teizo Kitagawa

研究成果: Article査読

38 被引用数 (Scopus)

抄録

A structural model of amyloid fibril formed by the #21-31 fragment of β2-microglobulin is proposed from microscope IR measurements on specifically 13C-labeled peptide fibrils and Raman spectra of the dispersed fibril solution. The 13C-shifted amide frequency indicated the secondary structure of the labeled residues. The IR spectra have demonstrated that the region between F22 and V27 forms the core part with the extended β-sheet structure. Raman spectra indicated the formation of a dimer with a disulfide bridge between C25 residues.

本文言語English
ページ(範囲)7988-7989
ページ数2
ジャーナルJournal of the American Chemical Society
127
22
DOI
出版ステータスPublished - 2005 6月 8

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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