Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

研究成果: Article

6 引用 (Scopus)

抜粋

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.

元の言語English
ページ(範囲)1490-1495
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
56
発行部数10
DOI
出版物ステータスPublished - 2008 10 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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