Structural determination of the oligosaccharides in the milk of a giant anteater (Myrmecophaga tridatyla)

Tadasu Urashima, Miki Komoda, Sadaki Asakuma, Yusuke Uemura, Kenji Fukuda, Tadao Saito, Olav T. Oftedal

    研究成果: Article査読

    9 被引用数 (Scopus)

    抄録

    There appears to be strong evidence supporting four major clades of placental mammals: (i) Afrotheria; (ii) Xenarthea; (iii) Euarchontoglires; and (iv) Laurasiathera. This is the first study in which the carbohydrates have been analyzed in the milks of Xenarthea. Our aim was to clarify whether the saccharides of giant anteater milk resemble those of other eutherian species, especially of the Asian elephant, which is one of the Afrotherea. We found that lactose is a dominant saccharide in this milk, as it is in that of most eutherians, and that the milk contains smaller amounts of oligosaccharides, whose structures were determined as Gal(α1-3)Gal(β1-4)Glc (isoglobotriose), Neu5Ac(α2-6)Gal(β1-4)Glc (6'-N- acetylneuraminyllactose), Neu5Gc(α2-6)Gal(β1-4)Glc (6'-N-glycolylneuraminyllactose), Neu5Ac(α2-6)Gal(β1-4) GlcNAc(β1-3)Gal(β1-4)Glc (LST c) and Neu5Gc(α2-6)Gal(β1-4) GlcNAc(β1-3)Gal(β1-4)Glc. This pattern of milk carbohydrates is rather close to that of the milks of other eutherian species. It is notable that the milk contained oligosaccharides with Neu5Gc residues but no oligosaccharides containing α(2-3) linked Neu5Ac residues such as Neu5Ac(α2-3) Gal(β1-4)Glc.

    本文言語English
    ページ(範囲)699-709
    ページ数11
    ジャーナルAnimal Science Journal
    79
    6
    DOI
    出版ステータスPublished - 2008 12月 1

    ASJC Scopus subject areas

    • 農業および生物科学(全般)

    フィンガープリント

    「Structural determination of the oligosaccharides in the milk of a giant anteater (Myrmecophaga tridatyla)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル