Structural basis of [NiFe] hydrogenase maturation by Hyp proteins

Satoshi Watanabe, Daisuke Sasaki, Taiga Tominaga, Kunio Miki

研究成果: Review article査読

28 被引用数 (Scopus)

抄録

[NiFe] hydrogenases catalyze reversible hydrogen production/consumption. The active site of [NiFe] hydrogenases contains a complex NiFe(CN)2CO center, and the biosynthesis/maturation of these enzymes is a complex and dynamic process, primarily involving six Hyp proteins (HypABCDEF). HypA and HypB are involved in the Ni insertion, whereas the other four Hyp proteins (HypCDEF) are required for the biosynthesis, assembly and insertion of the Fe(CN) 2CO group. Over the last decades, a large number of functional and structural studies on maturation proteins have been performed, revealing detailed functions of each Hyp protein and the framework of the maturation pathway. This article will focus on recent advances in structural studies of the Hyp proteins and on mechanistic insights into the [NiFe] hydrogenase maturation.

本文言語English
ページ(範囲)1089-1100
ページ数12
ジャーナルBiological Chemistry
393
10
DOI
出版ステータスPublished - 2012 10
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 臨床生化学

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