Structural basis for a Ca2+-Sensing functions of the metabotropic glutamate receptors

Yoshihiro Kubo, Tomoyuki Miyashita, Yoshimichi Murata

研究成果: Article査読

190 被引用数 (Scopus)

抄録

The metabotropic glutamate receptors (mGluRs) are widely distributed in the brain and play important roles in synaptic plasticity. Here it is shown that some types of mGluRs are activated not only by glutamate but also by extracellular Ca2+ (Ca2+(o)). A single amino acid residue was found to determine the sensitivity of mGluRs to Ca2+(o). One of the receptors, mGluR1α, but not its point mutant with reduced sensitivity to Ca2+(o), caused morphological changes when transfected into mammalian cells. Thus, the sensing of Ca2+(o) by mGluRs may be important in cells under physiological condition.

本文言語English
ページ(範囲)1722-1725
ページ数4
ジャーナルScience
279
5357
DOI
出版ステータスPublished - 1998 3 13
外部発表はい

ASJC Scopus subject areas

  • 一般

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