Strong and selective binding of amiloride to thymine base opposite AP sites in DNA duplexes: Simultaneous binding to DNA phosphate backbone

Chunxia Zhao, Qing Dai, Takehiro Seino, Ying Yu Cui, Seiichi Nishizawa, Norio Teramae

研究成果: Article査読

55 被引用数 (Scopus)

抄録

Amiloride (N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride) has two sets of hydrogen-bond forming sites suitable for target nucleotides and the phosphodiester DNA backbone by which a thymine base opposite an abasic site in DNA duplexes can be recognized with high selectivity and affinity, and it is applicable to the fluorescence detection of thymidine-related SNPs (single-nucleotide polymorphisms) of PCR amplification products.

本文言語English
ページ(範囲)1185-1187
ページ数3
ジャーナルChemical Communications
11
DOI
出版ステータスPublished - 2006 3月 13

ASJC Scopus subject areas

  • 触媒
  • 電子材料、光学材料、および磁性材料
  • セラミックおよび複合材料
  • 化学 (全般)
  • 表面、皮膜および薄膜
  • 金属および合金
  • 材料化学

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