Stimulatory effects of prostaglandin E2 on neurogenesis in the dentate gyrus of the adult rat

Katsuya Uchida, Kentarou Kumihashi, Satoshi Kurosawa, Tetsuya Kobayashi, Keiichi Itoi, Takeo Machida

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Neurogenesis in the dentate gyrus of adult rodents is elicited by transient global ischemia. Cyclooxygenase (COX) -2, a rate-limiting enzyme for prostanoid synthesis, is also induced by ischemia. We recently found that the administration of a non-selective COX inhibitor to ischemic animals suppressed cell proliferation in the subgranular zone (SGZ) at the dentate gyrus of the hippocampus. To clarify whether prostaglandin E2 (PGE2) synthesis by COX's is involved in neurogenesis, sulprostone, an analogue of PGE2, was injected into the rat hippocampus. Sulprostone injection increased the number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the SGZ. BrdU-positive cells also expressed polysialylated isoforms of neural cell adhesion molecule and neuronal nuclear antigen. These results suggest that PGE2 plays an important role in the proliferation of cells in the SGZ.

本文言語English
ページ(範囲)1211-1216
ページ数6
ジャーナルZoological Science
19
11
DOI
出版ステータスPublished - 2002 11 1

ASJC Scopus subject areas

  • Animal Science and Zoology

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