Steroid hormones do not reactivate Neospora caninum in ovariectomized mice

Atsushi Kobayashi, Seiji Katagiri, Takashi Kimura, Kenji Ochiai, Takashi Umemura

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The direct effects of three steroid hormones (progesterone, estradiol-17β and corticosterone) on the growth of Neospora caninum (N. caninum) tachyzoite were examined in Vero cells. Subsequently, ovariectomized BALB/c mice infected with N. caninum were treated with physiological concentrations of the steroid hormones for 1 or 2 weeks. These hormones had no direct effect on the parasite growth in vitro. In the infected mice, there was no significant difference in the parasite distribution and histopathological changes between the hormone-injected and control groups. No mice showed parasitemia at the time of autopsy. These results suggest that physiological levels of steroid hormones (progesterone, estradiol-17β and corticosterone) do not reactivate N. caninum in mice.

本文言語English
ページ(範囲)773-777
ページ数5
ジャーナルJournal of Veterinary Medical Science
64
9
DOI
出版ステータスPublished - 2002 9月

ASJC Scopus subject areas

  • 獣医学(全般)

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