抄録
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1215-1224 |
| ページ数 | 10 |
| ジャーナル | Chirality |
| 巻 | 30 |
| 号 | 11 |
| DOI | |
| 出版ステータス | Published - 2018 11 |
| 外部発表 | はい |
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry