Stereoselective conjugate addition of ketones to alkylidene malonates using thiourea-sulfonamide organocatalyst

Masahiro Kawada, Kosuke Nakashima, Shin ichi Hirashima, Toru Sakagami, Yuji Koseki, Tsuyoshi Miura

研究成果: Article査読

抄録

In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.

本文言語English
ページ(範囲)1215-1224
ページ数10
ジャーナルChirality
30
11
DOI
出版ステータスPublished - 2018 11
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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