Stereoselective approach to the DEF ring system of terpendole e

Takaaki Teranishi, Shigefumi Kuwahara

    研究成果: Article査読

    6 被引用数 (Scopus)

    抄録

    Diastereoselective construction of a DEF ring model of terpendole E, a M phase-specific antimitotic natural product, has been achieved from a known bicyclic keto ester by a 10-step (or 12-step) sequence that features an efficient one-pot intramolecular etherification of an olefinic alcohol with mCPBA. The synthesis proceeded in an excellent overall yield of 36% through 10 steps or in 56% via 12 steps which involved a highly diastereoselective reduction of a ketone derived from an undesired diastereomeric alcohol intermediate.

    本文言語English
    ページ(範囲)1486-1487
    ページ数2
    ジャーナルTetrahedron Letters
    55
    8
    DOI
    出版ステータスPublished - 2014 2月 19

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

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