Stereodivergent Synthesis and Configurational Assignment of the C1-C15 Segment of Amphirionin-5

Moemi Kanto, Sota Sato, Masashi Tsuda, Makoto Sasaki

    研究成果: Article査読

    7 被引用数 (Scopus)

    抄録

    The relative configuration of the C3-C12 portion of amphirionin-5, a novel marine polyketide with potent cell proliferation-promoting activity, was established by the stereodivergent synthesis of six diastereomeric model compounds and comparison of their NMR spectroscopic data with those reported for the natural product. This study led to the elucidation of the relative configuration between C4/C5 and C9/C12 and to the reassignment of the proposed configuration of the C9 position of amphirionin-5.

    本文言語English
    ページ(範囲)9105-9121
    ページ数17
    ジャーナルJournal of Organic Chemistry
    81
    19
    DOI
    出版ステータスPublished - 2016 10 7

    ASJC Scopus subject areas

    • Organic Chemistry

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