抄録
The first total synthesis of four naturally occurring dihydro-β-agarofuran esters has been accomplished via a highly stereocontrolled 14-step access to their common core triol, (-)-isocelorbicol. A semipinacol rearrangement of an epoxy alcohol to install a quaternary carbon, diastereoselective conjugate reduction of a spirocyclic butenolide for the establishment of a methyl-bearing chiral center, and ring-closing metathesis to construct the decalin ring system were exploited as the key steps for the high-yielding synthesis of (-)-isocelorbicol.
本文言語 | English |
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ページ(範囲) | 9234-9238 |
ページ数 | 5 |
ジャーナル | Organic letters |
巻 | 22 |
号 | 23 |
DOI | |
出版ステータス | Published - 2020 12月 4 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学