Stereo-controlled synthesis of analogs of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK

Satoru Tamura, Masayuki Tonokawa, Nobutoshi Murakami

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Stereo-controlled construction of the core structure of peumusolide A (1), α-alkylidene-β-hydroxy-γ-methylenebutyrolactone, was developed by a combination of regio- and stereo-selective hydroiodination of 2-yn-1-ol and asymmetric reduction of 1-yn-4-en-3-one as the key reactions. By using this protocol, all the four stereoisomers of the analog of 1 were synthesized from the common starting material.

本文言語English
ページ(範囲)3134-3137
ページ数4
ジャーナルTetrahedron Letters
51
23
DOI
出版ステータスPublished - 2010 6 9

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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